anti- Bestrophin-1 antibody

Illuminate the intricate dynamics of cellular chloride channels with our Anti-Bestrophin-1 Antibody. This 100µg antibody is your beacon for exploring the functions of Bestrophin-1, a pivotal protein involved in chloride ion transport and cellular homeostasis.

Engineered for precision and reliability, this antibody excels in various applications, from immunofluorescence to co-immunoprecipitation. Its exceptional specificity and sensitivity ensure that your experiments yield dependable and reproducible results, making it an essential tool in your research.

Bestrophin-1 plays a central role in the regulation of chloride ion movement across cellular membranes, with far-reaching implications in cellular physiology. With this antibody in your arsenal, you're well-equipped to investigate its multifaceted functions. Whether you're probing its roles in ion channel activity, membrane potential, or its potential relevance in disease mechanisms, this antibody stands as your trusted research companion.

Illuminate the path to scientific discovery by adding our Anti-Bestrophin-1 Antibody to your experiments today. Shed light on the secrets of Bestrophin-1 and gain deeper insights into the dynamic world of cellular chloride channels and ion transport.

Product Name

Bestrophin-1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

IMMUNOGEN INFORMATION

Immunogen

bestrophin 1

Synonyms

BEST

Observed MW

70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

O76090

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