anti- BHLHE22 antibody

Explore the complex landscape of transcriptional regulation with our Anti-BHLHE22 Antibody. This 100µg antibody is your guiding light in deciphering the functions of BHLHE22, a transcription factor intricately involved in cellular processes.

Crafted with precision and rigor, this antibody delivers exceptional performance across various applications, from chromatin immunoprecipitation to immunohistochemistry. Its high specificity and sensitivity ensure accurate and reproducible results, making it an indispensable tool in your transcriptional research.

BHLHE22, also known as BHLHB5 or bHLHb5, plays a pivotal role in neural development and function. With this antibody at your disposal, you can delve into its functions, exploring its impact on gene regulation, neural differentiation, and its relevance to neurological disorders.

Shed light on the mysteries of transcriptional control by incorporating our Anti-BHLHE22 Antibody into your experiments. Illuminate the intricate world of transcription factors, paving the way for groundbreaking discoveries in the fields of neuroscience, developmental biology, and beyond.

Product Name

BHLHE22 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.

IMMUNOGEN INFORMATION

Immunogen

basic helix-loop-helix family, member e22

Synonyms

BHLHB5, TNRC20

Observed MW

37 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:200-1:1000; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q8NFJ8

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