anti- BHLHE41 antibody

Illuminate the world of transcription regulation with our Anti-BHLHE41 Antibody. This 100µg antibody is your guiding beacon in deciphering the functions of BHLHE41, a transcription factor that orchestrates a myriad of cellular processes.

Designed with precision and rigor, this antibody delivers exceptional performance across various applications, from chromatin immunoprecipitation to immunofluorescence. Its high specificity and sensitivity ensure accurate and reproducible results, making it an indispensable tool in your transcriptional research.

BHLHE41, also known as DEC2, plays a pivotal role in circadian rhythms, immune responses, and other critical cellular functions. With this antibody at your disposal, you can delve into its functions, exploring its involvement in gene regulation, cell differentiation, and its relevance to various diseases.

Uncover the mysteries of cellular regulation by incorporating our Anti-BHLHE41 Antibody into your experiments. Shine a light on the complex world of transcription factors, paving the way for groundbreaking discoveries in the fields of chronobiology, immunology, and beyond.

Product Name

BHLHE41 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

IMMUNOGEN INFORMATION

Immunogen

basic helix-loop-helix family, member e41

Synonyms

BHLHB3, DEC2, SHARP1

Observed MW

51 kDa, 75 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:1000-1:2000

UNIPROT INFORMATION

UniProt ID

Q9C0J9

IMAGES