anti- BLK antibody

Delve into the world of immune regulation and B cell signaling with our Anti-BLK Antibody. This 100µg antibody is your invaluable tool for investigating the role of B Lymphocyte Kinase (BLK) in immune responses, autoimmunity, and lymphocyte development.

Carefully crafted for precision and reliability, this antibody offers outstanding specificity and sensitivity, ensuring accurate results in various applications, including flow cytometry, western blotting, and immunohistochemistry. Whether you're studying B cell biology, antibody production, or autoimmune diseases, this antibody is your trusted research companion.

BLK is a critical kinase involved in B cell receptor (BCR) signaling, making it a key player in humoral immunity and autoimmunity. Dysregulation of BLK has been implicated in various autoimmune diseases and B cell malignancies, highlighting its importance in immunology research.

With our Anti-BLK Antibody, you can uncover the intricate roles of BLK in immune responses, potentially contributing to advancements in immunotherapies and autoimmune disease treatments.

Product Name

BLK antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor(BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor(BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor(pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.

IMMUNOGEN INFORMATION

Immunogen

B lymphoid tyrosine kinase

Observed MW

58 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P51451

IMAGES