anti- BLNK antibody

Unravel the signaling functions of BLNK with our Anti-BLNK Antibody, now available in a 100µg size. This antibody is your tool for investigating the roles and mechanisms of BLNK, a key adaptor protein in B-cell receptor signaling.

Engineered for precision and reliability, this antibody offers exceptional specificity and sensitivity, ensuring accurate results in applications such as western blotting, immunoprecipitation, and flow cytometry. Whether you're studying BLNK's involvement in immune responses, lymphocyte activation, or antibody production, this antibody enhances your research capabilities.

BLNK, also known as B-cell linker protein, serves as a critical scaffold protein that facilitates signal transduction from the B-cell receptor to downstream effectors, playing a crucial role in B-cell activation and antibody-mediated immune responses.

With our Anti-BLNK Antibody, you can unravel BLNK's signaling functions, contribute to the understanding of B-cell biology, and potentially advance research in immunology and autoimmune diseases. Elevate your research in cell signaling and molecular immunology with this precision antibody.

Product Name

BLNK antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Functions as a central linker protein, downstream of the B-cell receptor(BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3(PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

IMMUNOGEN INFORMATION

Immunogen

B-cell linker

Synonyms

BASH, SLP65

Observed MW

68 kDa, 70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q8WV28

IMAGES