anti- BMI1 antibody

Dive into the world of cellular regulation with our Anti-BMI1 Antibody. This 100µg antibody is your essential tool for exploring the functions of BMI1 (B-Cell-Specific Moloney Murine Leukemia Virus Integration Site 1), a critical protein involved in stem cell maintenance and gene expression control.

Designed for precision and reliability, this antibody boasts exceptional specificity and sensitivity, ensuring accurate results in various applications, including immunofluorescence, western blotting, and chromatin immunoprecipitation. Whether you're studying cancer biology, epigenetics, or stem cell research, this antibody is a cornerstone of your investigations.

BMI1 is a core component of the Polycomb Repressive Complex 1 (PRC1), and it plays pivotal roles in maintaining stem cell pluripotency and regulating gene expression. Dysregulation of BMI1 has profound implications in cancer and developmental disorders, making it a compelling target for research.

With our Anti-BMI1 Antibody, you can delve deep into the intricate world of BMI1-mediated cellular regulation, potentially contributing to advances in cancer therapeutics, regenerative medicine, and epigenetic therapies.

Product Name

BMI1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of a Polycomb group(PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

IMMUNOGEN INFORMATION

Immunogen

BMI1 polycomb ring finger oncogene

Synonyms

BMI1, PCGF4, Polycomb complex protein BMI 1, RING finger protein 51, RNF51

Observed MW

37 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P35226

IMAGES