anti- BORIS antibody

Explore the functionality of BORIS (Brother of the Regulator of Imprinted Sites) with our Anti-BORIS Antibody, available in a 100µg size. This high-quality antibody is your gateway to unraveling the roles and mechanisms of BORIS in epigenetic regulation and gene expression.

Engineered for precision and reliability, this antibody offers exceptional specificity and sensitivity, ensuring accurate results in applications such as chromatin immunoprecipitation, immunofluorescence, and RNA sequencing. Whether you're studying BORIS's involvement in genome imprinting, cancer progression, or stem cell biology, this antibody empowers your research with accuracy and versatility.

BORIS, a paralog of the CTCF (CCCTC-binding factor) protein, is a chromatin regulator implicated in epigenetic control of gene expression and chromatin structure. Its aberrant expression is associated with various cancers.

With our Anti-BORIS Antibody, you can explore BORIS's functionality, investigate its chromatin-binding sites, and potentially advance research in epigenetics and oncology. Elevate your research in molecular biology and epigenetic regulation with this precision antibody.

Product Name

BORIS antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CTCFL, also named BORIS(for brother of the regulator of imprinted sites) is a paralogue of the 11 zinc-finger transcription factor, CTCF. It is predominantly expressed in spermatocytes in the testis, also can be found in tumors and cancer cell lines. It mainly participates in insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. It has a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region(ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.

IMMUNOGEN INFORMATION

Immunogen

CCCTC-binding factor(zinc finger protein)-like

Synonyms

BORIS, Cancer/testis antigen 27, CCCTC binding factor, CT27, CTCF like protein, CTCF paralog, CTCF T, CTCFL, dJ579F20.2, Zinc finger protein CTCF T

Observed MW

75 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:500-1:2000; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q8NI51

IMAGES