anti- BRCC3 antibody

Investigate the biology of BRCC3 (BRCA1-BRCA2 Containing Complex Subunit 3) with our Anti-BRCC3 Antibody, available in a 100µg size. This high-quality antibody is your essential tool for exploring the roles and functions of BRCC3 in DNA repair, genome stability, and cancer biology.

Engineered for precision and reliability, this antibody offers exceptional specificity and sensitivity, ensuring accurate results in applications such as immunoprecipitation, western blotting, and immunofluorescence. Whether you're studying BRCC3's involvement in the BRCA1-BRCA2 complex, ubiquitin-mediated DNA repair, or tumorigenesis, this antibody enhances your research capabilities.

BRCC3 is a critical component of the BRCA1-BRCA2-containing complex, which plays a pivotal role in DNA double-strand break repair, homologous recombination, and maintenance of genomic integrity.

With our Anti-BRCC3 Antibody, you can investigate BRCC3's functionality, dissect its interactions within the BRCA1-BRCA2 complex, and potentially advance research in cancer biology and DNA repair mechanisms. Elevate your research in genome stability and oncology with this precision antibody.

Product Name

BRCC3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains(PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks(DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks(DSBs)(PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates(PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex(CSN), via the interaction of the BRISC complex with the CSN complex(PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1(PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression(PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide(LPS) via its role in IFNAR1 deubiquitination(PubMed:24075985).

IMMUNOGEN INFORMATION

Immunogen

BRCA1/BRCA2-containing complex, subunit 3

Synonyms

BRCC36, C6.1A, CXorf53

Observed MW

65-70kd

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P46736

IMAGES