anti- BRD7 antibody

Investigate BRD7 (Bromodomain-Containing Protein 7) with our Anti-BRD7 Antibody, available in a 100µg size. This high-quality antibody is your indispensable tool for unraveling the roles and functions of BRD7 in chromatin remodeling, transcriptional regulation, and epigenetic control.

Engineered for precision and reliability, this antibody offers exceptional specificity and sensitivity, ensuring accurate results in applications such as chromatin immunoprecipitation (ChIP), immunofluorescence, and co-immunoprecipitation. Whether you're exploring BRD7's involvement in enhancer biology, histone modification, or tumor suppression, this antibody empowers your research with accuracy and versatility.

BRD7 is a member of the bromodomain and extraterminal (BET) family of proteins, recognized for their critical roles in gene expression control and epigenetic regulation. BRD7 is associated with chromatin and is implicated in the modulation of transcriptional activity.

With our Anti-BRD7 Antibody, you can investigate BRD7's functionality, explore its interactions with transcriptional machinery, and potentially advance research in epigenetics and cancer biology. Elevate your research in chromatin dynamics and gene regulation with this precision antibody.

Product Name

BRD7 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR(By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9'(H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

IMMUNOGEN INFORMATION

Immunogen

bromodomain containing 7

Synonyms

BP75, CELTIX1

Observed MW

70-74kd

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NPI1

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