anti- BRD8 antibody

Explore BRD8 (Bromodomain-Containing Protein 8) with our Anti-BRD8 Antibody, available in a 100µg size and featuring a polyclonal design for enhanced versatility. This high-quality antibody is your versatile tool for investigating BRD8's roles and functions in chromatin remodeling, transcriptional regulation, and epigenetic control.

Engineered for precision and reliability, this polyclonal antibody is suitable for applications such as western blotting, immunohistochemistry, and co-immunoprecipitation. Whether you're studying BRD8's involvement in enhancer biology, histone acetylation, or cancer epigenetics, this antibody enhances your research capabilities.

BRD8 is a member of the bromodomain and extraterminal (BET) family of chromatin readers, known for their essential roles in gene expression control and epigenetic regulation. BRD8 is associated with chromatin and participates in the regulation of transcriptional activity.

With our Anti-BRD8 Antibody, you can thoroughly explore BRD8's functionality, investigate its interactions with histone modifiers, and potentially advance research in epigenetics and cancer biology. Elevate your research in gene regulation and chromatin dynamics with this precision antibody.

Product Name

BRD8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

IMMUNOGEN INFORMATION

Immunogen

bromodomain containing 8

Synonyms

SMAP, SMAP2

Observed MW

120 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:1000

UNIPROT INFORMATION

UniProt ID

Q9H0E9

IMAGES