anti- BRD8 antibody

Study BRD8 (Bromodomain-Containing Protein 8) with our Anti-BRD8 Antibody, available in a 100µg size. This high-quality antibody is your essential tool for investigating the roles and functions of BRD8 in chromatin remodeling, transcriptional regulation, and epigenetic control.

Engineered for precision and versatility, this antibody is suitable for applications such as chromatin immunoprecipitation (ChIP), immunofluorescence, and co-immunoprecipitation. Whether you're exploring BRD8's involvement in histone modification, enhancer activation, or developmental biology, this antibody offers accuracy and reliability.

BRD8 is a member of the bromodomain and extraterminal (BET) family of proteins, known for their key roles in gene expression control and epigenetic regulation. BRD8 associates with chromatin and is implicated in the modulation of transcriptional activity.

With our Anti-BRD8 Antibody, you can delve into BRD8's functionality, investigate its interactions with transcriptional machinery, and potentially advance research in epigenetics and developmental biology. Elevate your research in chromatin dynamics and gene regulation with this precision antibody.

Product Name

BRD8 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

IMMUNOGEN INFORMATION

Immunogen

bromodomain containing 8

Synonyms

SMAP, SMAP2

Observed MW

120 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q9H0E9

IMAGES