anti- BRSK2 antibody

Explore BRSK2 (Serine/Threonine-Protein Kinase BRSK2) with our Anti-BRSK2 Antibody, available in a 100µg size. This high-quality antibody is your versatile tool for investigating BRSK2's functions in cell signaling, neuronal development, and kinase activity.

Engineered for precision and reliability, this antibody ensures exceptional sensitivity in applications such as immunofluorescence, western blotting, and kinase assays. Whether you're studying BRSK2's involvement in neuronal polarity, axon formation, or kinase regulation, this antibody enhances your research capabilities.

BRSK2 is a serine/threonine-protein kinase known for its roles in neuronal differentiation and cellular polarity. Understanding BRSK2's functions and signaling pathways is crucial in deciphering its contributions to neurobiology and cell biology.

With our Anti-BRSK2 Antibody, you can precisely investigate BRSK2's functionality, explore its substrates, and potentially advance research in neuronal development and kinase signaling. Elevate your research in cell polarity and neurogenesis with this precision antibody.

Product Name

BRSK2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion(PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion(PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum(ER) stress.

IMMUNOGEN INFORMATION

Immunogen

BR serine/threonine kinase 2

Synonyms

C11orf7, PEN11B, SADA, STK29

Observed MW

80-88kd

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q8IWQ3

IMAGES