anti- BUB1 antibody

Uncover the pivotal roles of BUB1 (Budding Uninhibited by Benzimidazoles 1) with our Anti-BUB1 Antibody, available in a 100µg size. This high-quality antibody is your indispensable tool for exploring BUB1's functions in cell cycle regulation, kinetochore assembly, and mitotic checkpoint control.

Engineered for precision and versatility, this antibody ensures exceptional sensitivity in applications such as immunofluorescence, western blotting, and immunoprecipitation. Whether you're studying BUB1's involvement in chromosome segregation, spindle checkpoint signaling, or its interactions with other mitotic regulators, this antibody empowers your research with accuracy and reliability.

BUB1, a serine/threonine kinase, plays a critical role in ensuring accurate chromosome segregation during cell division. Understanding BUB1's functions and its molecular interactions is fundamental in deciphering its contributions to genome stability and cell cycle progression.

With our Anti-BUB1 Antibody, you can precisely investigate BUB1's functionality, explore its role in mitotic regulation, and potentially advance research in cancer biology and therapies targeting cell cycle checkpoints. Elevate your research in cell division and genomic integrity with this precision antibody.

Product Name

BUB1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

budding uninhibited by benzimidazoles 1 homolog (yeast)

Synonyms

BUB1L

Observed MW

133 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

O43683

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