anti- BUB3 antibody

xplore the multifaceted functions of BUB3 (Mitotic Checkpoint Protein BUB3) with our Anti-BUB3 Antibody, available in a 100µg size. This high-quality antibody is your versatile tool for studying BUB3, a crucial component of the mitotic checkpoint that ensures accurate chromosome segregation during cell division.

Engineered for precision and reliability, this antibody ensures exceptional sensitivity in applications such as western blotting, immunohistochemistry, and immunofluorescence. Whether you're exploring BUB3's role in spindle checkpoint control, kinetochore-microtubule attachment, or its interactions with other mitotic checkpoint proteins, this antibody enhances your research capabilities.

BUB3 plays a vital role in safeguarding genomic stability by preventing premature anaphase and ensuring proper chromosome alignment. Dysregulation of BUB3 can lead to chromosome missegregation and aneuploidy, which are hallmarks of cancer.

With our Anti-BUB3 Antibody, you can delve into BUB3's functionality, explore its impact on the mitotic checkpoint, and potentially advance research in cancer biology and cell division regulation. Elevate your research in spindle assembly checkpoint mechanisms and chromosome stability with this precision antibody.

Product Name

BUB3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule(K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome(APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

IMMUNOGEN INFORMATION

Immunogen

budding uninhibited by benzimidazoles 3 homolog(yeast)

APPLICATION

Tested Application

ELISA, IF

Recommended Dilution

IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O43684