anti- CACNA1S antibody

Delve into the intricate functions of CACNA1S with our Anti-CACNA1S Antibody, now available in a 100µg vial. CACNA1S, a subunit of the dihydropyridine receptor complex, is a critical component in muscle excitation-contraction coupling and calcium ion homeostasis.

Our meticulously developed and rigorously tested Anti-CACNA1S Antibody empowers you to explore the functions and roles of CACNA1S with precision and accuracy. Whether you're investigating its roles in muscle contraction, neuromuscular diseases, or its implications in channelopathies, this antibody provides the specificity and sensitivity necessary for reliable results.

This versatile antibody is optimized for various applications, including immunohistochemistry, Western blotting, and immunoprecipitation. With its robust performance, you can confidently investigate CACNA1S in diverse experimental setups.

Each 100µg vial of this antibody offers value and flexibility, allowing you to advance scientific knowledge and uncover the complexities of CACNA1S with confidence.

Product Name

CACNA1S antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Voltage-sensitive calcium channels(VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting(L-type) calcium channels belong to the 'high-voltage activated'(HVA) group. They are blocked by dihydropyridines(DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA(omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA(omega-CTx-GVIA) and omega-agatoxin-IVA(omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

IMMUNOGEN INFORMATION

Immunogen

calcium channel, voltage-dependent, L type, alpha 1S subunit

Synonyms

CACH1, CACN1, CACNL1A3

Observed MW

200-220kd

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q13698

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