anti- CALCOCO2 antibody

Delve into the intricacies of CALCOCO2 with our Anti-CALCOCO2 Antibody, now available in a 100µg vial. CALCOCO2, also known as calcium-binding and coiled-coil domain-containing protein 2, is a multifunctional protein involved in diverse cellular processes, including intracellular calcium regulation and vesicular trafficking.

Our meticulously developed and rigorously tested Anti-CALCOCO2 Antibody empowers you to explore the functions and roles of CALCOCO2 with precision and accuracy. Whether you're investigating its roles in calcium-dependent signaling, membrane trafficking, or its implications in neurodegenerative diseases, this antibody ensures reliable results.

This versatile antibody is optimized for various applications, including immunohistochemistry, Western blotting, and immunoprecipitation. With its robust performance, you can confidently investigate CALCOCO2 in diverse experimental setups.

Each 100µg vial of this antibody offers value and flexibility, allowing you to advance scientific knowledge and contribute to our understanding of CALCOCO2's significance in cellular physiology and disease with confidence.

Product Name

CALCOCO2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy(PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation(PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C(PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion(PubMed:17635994).

IMMUNOGEN INFORMATION

Immunogen

calcium binding and coiled-coil domain 2

Synonyms

NDP52

Observed MW

52 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

Q13137

IMAGES