anti- Caspase 12 antibody

Explore the role of Caspase 12 in endoplasmic reticulum stress-induced apoptosis with our Anti-Caspase 12 Antibody, now available in a 100µg size. Caspase 12 is a key player in endoplasmic reticulum-mediated apoptosis, and its detection is crucial for understanding the mechanisms underlying this form of programmed cell death.

Our 100µg antibody is designed to provide high specificity and sensitivity, making it an invaluable tool for your research in cell biology, apoptosis, and stress responses. This antibody ensures that you have an ample supply for multiple experiments, promoting cost-effectiveness and consistent results.

In summary, our range of Caspase antibodies, available in 100µg sizes and various types (monoclonal and polyclonal), empowers researchers to investigate programmed cell death, inflammation, and stress responses with confidence and precision.

Product Name

Caspase 12 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. It is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels. This antibody detects endogenous levels of full-length caspase-12 protein (50 kDa) and its cleaved product (40-44 kDa).

IMMUNOGEN INFORMATION

Immunogen

caspase 12(gene/pseudogene)

Synonyms

CASP12, CASP-12, CASP12P1

Observed MW

36-42 kDa, 50 kDa

APPLICATION

Tested Application

ELISA, IF, IHC, WB, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q6UXS9

IMAGES