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FNab01293

anti- Caspase 8 antibody

anti- Caspase 8 antibody

$290.00 USD
$290.00 USD
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Our Anti-Caspase 8 Antibody (Polyclonal, 100µg) is a versatile tool for researchers exploring apoptosis and immune signaling pathways. Caspase 8, a critical initiator caspase, orchestrates cell death induced by death receptors. This polyclonal antibody is meticulously designed to target Caspase 8 specifically, ensuring precise results in your experiments.

With 100µg of antibody per vial, you'll have an abundant supply for multiple experiments, reducing the need for frequent reordering. Produced in a rabbit host, this antibody offers excellent sensitivity and specificity, making it ideal for various applications, including Western blotting, immunohistochemistry, and flow cytometry.

Our Anti-Caspase 8 Antibody (Polyclonal, 100µg) empowers researchers to explore apoptosis and immune signaling pathways with confidence. Its high-quality performance guarantees the accuracy of your results, contributing to the advancement of scientific knowledge in these critical fields.

Product Name

Caspase 8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.

IMMUNOGEN INFORMATION

Immunogen

caspase 8, apoptosis-related cysteine peptidase

Synonyms

Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5

Observed MW

50-55 kDa, 25-32 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP, IF

Recommended Dilution

WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:100; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q14790

IMAGES

 

Immunohistochemistry of paraffin-embedded human lymphoma using FNab01293(CASP8 antibody) at dilution of 1:50
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HepG2 cells using FNab01293 （Caspase 8 Antibody）at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
IP Result of anti-CASP8 (IP:FNab01293, 3ug; Detection:FNab01293 1:500) with HeLa cells lysate 2500ug.
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab01293(CASP8 antibody) at dilution of 1:1000

 

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