anti- CBL antibody

Our Anti-CBL Antibody (100µg) is a critical asset for researchers investigating Casitas B-lineage lymphoma proto-oncogene (CBL) and its roles in cellular signaling, growth regulation, and oncogenesis. CBL is a crucial protein involved in modulating receptor tyrosine kinase signaling and ubiquitin-mediated protein degradation. This antibody, meticulously designed to specifically target CBL, ensures precise and reliable results in your experiments.

With 100µg of this high-quality antibody per vial, you'll have an ample supply for multiple experiments, reducing the need for frequent reordering. Whether you're conducting co-immunoprecipitation assays, studying CBL's interaction with growth factor receptors, or exploring its involvement in cancer development, this antibody consistently delivers outstanding performance.

Researchers can rely on the exceptional specificity and sensitivity of this antibody, produced using advanced techniques and premium-grade materials. Its reliability makes it an indispensable asset for projects aimed at deciphering the complex roles of CBL in cellular processes and diseases.

Empower your research on cellular signaling and oncology with confidence using our Anti-CBL Antibody. By utilizing this antibody, you contribute to the broader understanding of signal transduction pathways and their critical roles in health and disease.

Product Name

CBL antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

IMMUNOGEN INFORMATION

Immunogen

Cas-Br-M (murine) ecotropic retroviral transforming sequence

Synonyms

CBL2, RNF55

Observed MW

117 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

P22681

IMAGES