anti- CBLC antibody

Our Anti-CBLC Antibody (100µg) is a valuable resource for researchers investigating Cas-Br-M (murine) ecotropic retroviral transforming sequence-like protein C (CBLC) and its involvement in cellular signaling, cancer progression, and receptor tyrosine kinase regulation. CBLC, a member of the CBL family of proteins, plays a vital role in modulating signal transduction pathways. This antibody, meticulously designed to specifically target CBLC, ensures precise and reliable results in your experiments.

With 100µg of this high-quality antibody per vial, you'll have an ample supply for multiple experiments, reducing the need for frequent reordering. Whether you're conducting Western blots, co-immunoprecipitation assays, or studying CBLC's interaction with oncogenic kinases, this antibody consistently delivers outstanding performance.

Researchers can rely on the exceptional specificity and sensitivity of this antibody, produced using advanced techniques and premium-grade materials. Its reliability makes it an indispensable asset for projects aimed at deciphering the complex roles of CBLC in cellular processes and diseases.

Empower your research on cellular signaling and cancer biology with confidence using our Anti-CBLC Antibody. By utilizing this antibody, you contribute to the broader understanding of signal transduction pathways and their critical roles in health and disease.

Product Name

CBLC antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

IMMUNOGEN INFORMATION

Immunogen

Cas-Br-M(murine) ecotropic retroviral transforming sequence c

Synonyms

CBL3, RNF57

Observed MW

52kd

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q9ULV8

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