anti- CD14 antibody

Investigate the role of CD14 in innate immunity with our Anti-CD14 Monoclonal Antibody, available in a 100µg size. CD14, a pivotal glycoprotein expressed on immune cell surfaces, plays a central role in recognizing and responding to bacterial lipopolysaccharides, initiating the innate immune response.

Our meticulously developed monoclonal antibody ensures unparalleled specificity and sensitivity, making it the ideal choice for a wide range of applications, including flow cytometry, immunohistochemistry, and immunoprecipitation. It provides the precision and reliability needed for accurate results in your CD14-related research.

With 100µg at your disposal, you have an ample supply for multiple experiments, minimizing interruptions and allowing you to maintain the momentum of your research.

Don't miss the opportunity to shed light on the essential functions of CD14 in innate immunity. With our Anti-CD14 Monoclonal Antibody, you can confidently delve into your research and uncover the secrets hidden within this critical immune receptor.

Product Name

CD14 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Coreceptor for bacterial lipopolysaccharide(PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide(LPS)(PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response(PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway(PubMed:16880211). Binds electronegative LDL(LDL(-)) and mediates the cytokine release induced by LDL(-)(PubMed:23880187).

IMMUNOGEN INFORMATION

Immunogen

CD14 molecule

Synonyms

CD14, CD14 molecule

Observed MW

50-55 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

P08571

IMAGES