anti- CD146/MCAM antibody

Investigate the multifaceted roles of CD146, also known as melanoma cell adhesion molecule (MCAM), in vascular biology and beyond with our Anti-CD146/MCAM Antibody, now available in a 100µg size. CD146 is a cell surface glycoprotein known for its involvement in cell adhesion, angiogenesis, and tumor progression.

Our meticulously developed monoclonal antibody ensures exceptional specificity and sensitivity, making it the ideal choice for various applications, including flow cytometry, Western blotting, and immunohistochemistry. It provides the precision and reliability needed for accurate results in your CD146-related research.

With 100µg at your disposal, you have a substantial supply for multiple experiments, ensuring the continuity of your research without frequent reordering.

Don't miss the opportunity to delve into the diverse functions of CD146 in vascular biology and disease. With our Anti-CD146/MCAM Antibody, you can confidently advance your research and uncover the secrets hidden within this critical cell surface molecule.

Product Name

CD146/MCAM antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CD146, also known as melanoma cell adhesion molecule(MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin(Ig) superfamily(PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells(CECs)(PMID: 19356677).

IMMUNOGEN INFORMATION

Immunogen

melanoma cell adhesion molecule

Synonyms

CD146, MCAM, MUC18,Cell surface glycoprotein MUC18,Cell surface glycoprotein P1H12,Melanoma cell adhesion molecule,Melanoma-associated antigen A32,Melanoma-associated antigen MUC18

Observed MW

113-120 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, FC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P43121

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