anti- CD22 antibody

Delve into the intricate world of B cell biology with our Anti-CD22 Monoclonal Antibody, available in a 100µg size. CD22, also known as Siglec-2, is a cell surface protein predominantly expressed on B cells, where it plays a crucial role in B cell signaling, activation, and tolerance.

Our meticulously developed monoclonal antibody ensures exceptional specificity and sensitivity, making it the ideal choice for various applications, including flow cytometry, Western blotting, and immunohistochemistry. It provides the precision and reliability needed for accurate results in your CD22-related research.

With 100µg at your disposal, you have a substantial supply for multiple experiments, ensuring the continuity of your research without frequent reordering.

Unlock the mysteries of CD22 in B cell biology and its therapeutic implications in autoimmune diseases and B cell malignancies. With our Anti-CD22 Monoclonal Antibody, you can confidently advance your research and contribute to advancements in immunology and targeted therapies.

Product Name

CD22 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

IMMUNOGEN INFORMATION

Immunogen

CD22 molecule

Synonyms

B cell receptor CD22, BL CAM, CD22, CD22 molecule, SIGLEC 2, SIGLEC2, T cell surface antigen Leu 14

Observed MW

135 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB : 1:1000-1:10000
IHC : 1:200-1:800

UNIPROT INFORMATION

UniProt ID

P20273

IMAGES