anti- CD244 antibody

Embark on a journey to investigate immune regulation with our Anti-CD244 Antibody, now available in a 100µg size. CD244, also known as 2B4 (natural killer cell receptor 2B4), is a cell surface receptor expressed on natural killer (NK) cells and certain T-cell subsets, where it plays a critical role in immune cell activation and cytotoxicity.

Our meticulously developed antibody ensures exceptional specificity and sensitivity, making it the ideal choice for various applications, including flow cytometry, Western blotting, and immunohistochemistry. It provides the precision and reliability needed for accurate results in your CD244-related research.

With 100µg at your disposal, you have a substantial supply for multiple experiments, ensuring the continuity of your research without frequent reordering.

Uncover the multifaceted functions of CD244 in immune cell regulation and its implications in cancer immunotherapy and infectious diseases. With our Anti-CD244 Antibody, you can confidently advance your research and contribute to advancements in immunology and targeted therapies.

Product Name

CD244 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Heterophilic receptor of the signaling lymphocytic activation molecule(SLAM) family; its ligand is CD48. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer(NK) cell receptor(PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN(PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2(PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis(PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells(By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1(PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells(PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells(By similarity). Inhibits inflammatory responses in dendritic cells(DCs)(By similarity).

IMMUNOGEN INFORMATION

Immunogen

CD244 molecule, natural killer cell receptor 2B4

Synonyms

2B4, CD244, h2B4, NAIL, NKR2B4, SLAMF4

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9BZW8

IMAGES