anti- CD33 antibody

Embark on a journey into the realm of myeloid cell research with our Anti-CD33 Antibody, now available in a 100µg size. CD33, a sialic acid-binding immunoglobulin-like lectin (Siglec), is primarily expressed on myeloid cells, including granulocytes, monocytes, and dendritic cells. It serves as a valuable marker for myeloid cell identification and is implicated in various immune-related disorders, making it a subject of intense research interest.

Our monoclonal antibody offers high specificity and sensitivity, making it an ideal choice for researchers investigating myeloid cell biology. With 100µg of this antibody, you'll have a substantial supply for multiple experiments, ensuring the uninterrupted progression of your research.

Explore the intricate functions of CD33 in myeloid cell adhesion, immune regulation, and its potential as a therapeutic target in diseases such as acute myeloid leukemia (AML). Investigate the molecular mechanisms underlying CD33-mediated processes, contributing to our understanding of immune-related disorders and therapeutic interventions.

Product Name

CD33 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia(in vitro).

IMMUNOGEN INFORMATION

Immunogen

CD33 molecule

Synonyms

SIGLEC3

Observed MW

67 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P20138

IMAGES