anti- CD39 antibody

Venture into the realm of immune regulation and immune cell research with our Anti-CD39 Antibody, now available in a 100µg size. CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), is a key enzyme involved in the regulation of extracellular nucleotide levels, affecting immune responses, inflammation, and the tumor microenvironment.

This monoclonal antibody offers high specificity and sensitivity, making it an ideal choice for researchers investigating CD39-mediated immune modulation. With 100µg of this antibody, you'll have a substantial supply for multiple experiments, ensuring the uninterrupted progression of your research.

Explore the intricate mechanisms by which CD39 influences immune cell function, adenosine production, and its role in immunosuppression and cancer immunotherapy. Investigate the molecular intricacies of CD39-mediated processes, advancing our understanding of immune-related disorders and potential therapeutic interventions.

Product Name

CD39 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ENTPD1(Ectonucleoside triphosphate diphosphohydrolase 1) is also named as CD39, NTPDase 1, Ecto-ATPDase 1 and belongs to the GDA1/CD39 NTPase family. In the nervous system, it can hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission.It is a noncovalent tetrameric protein and that detergent inhibition of enzymatic activity is caused by dissociation of ectoapyrase tetramers into monomers(PMID: 9733785).And it is a 70-to 100-kDa protein that is heavily N-glycosylated(PMID:7930580). It has 3 isoforms produced by alternative splicing. CD39 preferentially occurred as a dimer that could be dissociated into monomeric forms.(PMID: 12694193). The soluble isoform of CD39(38-478 amino acid) locates to the extracellular part and FNab01474 recognizes both the 3 isoforms and soluble form of CD39(38-478aa) molecule.

IMMUNOGEN INFORMATION

Immunogen

ectonucleoside triphosphate diphosphohydrolase 1

Synonyms

ATPDase, CD39, DKFZp686D194, DKFZp686I093, Ecto apyrase, Ecto ATP diphosphohydrolase 1, Ecto ATPase 1, Ecto ATPDase 1, ENTPD1, FLJ40921, FLJ40959, NTPDase 1

Observed MW

75-95 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, FC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P49961

IMAGES