FineTest
SKU:FNab01483
anti- CD44 antibody
anti- CD44 antibody
Couldn't load pickup availability
Enter the world of cell adhesion, migration, and signaling with our Anti-CD44 Monoclonal Antibody, now available in a 100µg size. CD44, a multifunctional cell surface glycoprotein, is involved in numerous cellular processes, including cell adhesion, migration, lymphocyte activation, and tumor metastasis.
This monoclonal antibody offers exceptional specificity and sensitivity, ensuring accurate and reliable results for researchers investigating CD44-mediated functions in various biological contexts. With 100µg of this antibody, you'll have a generous supply for multiple experiments, reducing the need for frequent reordering and ensuring the continuity of your research.
Explore the intricate mechanisms by which CD44 participates in cell adhesion dynamics, extracellular matrix interaction, and its role in cancer biology and tissue regeneration. Investigate the molecular intricacies of CD44-mediated processes, contributing to our understanding of cell adhesion dynamics and potential therapeutic interventions.
-
Product Name
CD44 antibody
Size
100µg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Host
Mouse
Clonality
monoclonal
Isotype
IgG2a
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BACKGROUND
Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).
IMMUNOGEN INFORMATION
Immunogen
CD44 molecule(Indian blood group)
Synonyms
LHR, MDU2, MDU3, MIC4
Observed MW
80-95 kDa
APPLICATION
Tested Application
ELISA, WB, IHC, IF, FC
Recommended Dilution
WB: 1：500-1：5000; IHC: 1：50-1：200; IF: 1：10-1：100
UNIPROT INFORMATION
UniProt ID
IMAGES
-
Immunohistochemistry of paraffin-embedded human lung cancer slide using FNab01483(CD44 Antibody) at dilution of 1:50 -
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01483(CD44 antibody) at dilution of 1:1000
