anti- CD45 antibody

Unlock the secrets of cellular identity and immune cell differentiation with our Anti-CD45 Polyclonal Antibody, now available in a convenient 100µg size. CD45, also known as leukocyte common antigen (LCA), is a critical cell surface marker expressed on all nucleated hematopoietic cells, enabling the precise characterization of immune cell populations.

Our meticulously developed polyclonal antibody, derived from rabbit hosts, offers exceptional sensitivity and versatility for various research applications. Whether you're investigating hematopoietic cell lineages, immune cell activation, or immune-related disorders, this antibody's polyclonal nature allows recognition of multiple epitopes, enhancing its utility in diverse research contexts.

With 100µg at your disposal, you have a generous supply for multiple experiments, reducing the need for frequent reordering and ensuring the continuity of your research.

Explore the intricate mechanisms by which CD45 facilitates immune cell identification, differentiation, and its pivotal role in hematopoiesis. Investigate the molecular intricacies of CD45-mediated processes, contributing to our understanding of immune cell biology and potential therapeutic interventions.

Product Name

CD45 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

IMMUNOGEN INFORMATION

Immunogen

protein tyrosine phosphatase, receptor type, C

Synonyms

B220, CD45, CD45R, GP180, L CA, LCA, Leukocyte common antigen, LY5, PTPRC, RPTPC, T200

Observed MW

190 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P08575

IMAGES