anti- CDC14B antibody

Dive into the world of cell cycle checkpoints and phosphatase regulation with our Anti-CDC14B Antibody, available in a 100µg size. CDC14B, a key member of the CDC14 phosphatase family, plays a critical role in controlling cell cycle progression and DNA damage responses.

Whether you're involved in immunoprecipitation, immunohistochemistry, or functional assays, this highly specific monoclonal antibody provides consistent and dependable results. It is an indispensable tool for advancing your understanding of CDC14B-mediated cell cycle control and its implications in genome stability and cancer biology.

Empower your research and contribute to scientific advancements with the trusted performance of our Anti-CDC14B Antibody. With this tool at your disposal, you'll be better equipped to unravel the complexities of CDC14B-mediated phosphatase regulation and its role in cellular homeostasis.

Product Name

CDC14B antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome(APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

IMMUNOGEN INFORMATION

Immunogen

CDC14 cell division cycle 14 homolog B

Observed MW

56 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

O60729

IMAGES