anti- CDK4 antibody

Embark on a journey into the world of cell cycle regulation with our Anti-CDK4 Antibody, now available in a 100µg size. Cyclin-dependent kinase 4 (CDK4) is a critical regulator of cell cycle progression, governing processes like G1 phase progression and cell proliferation. This monoclonal antibody offers remarkable specificity and sensitivity, making it a valuable tool for researchers investigating cell cycle dynamics, cancer biology, and the molecular mechanisms governing cellular growth.

With 100µg of this antibody, you'll have an ample supply for various experiments, ensuring the continuity of your research. Unravel the mysteries of CDK4 and its role in cell cycle checkpoints, its interactions with cyclins, and its potential implications in cancer therapeutics and targeted therapies.

Product Name

CDK4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

IMMUNOGEN INFORMATION

Immunogen

cyclin-dependent kinase 4

Synonyms

CDK4, Cell division protein kinase 4, CMM3, cyclin dependent kinase 4, PSK J3

Observed MW

32 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100

UNIPROT INFORMATION

UniProt ID

P11802

IMAGES