anti- CDK6 antibody

Delve into the complexities of cell cycle regulation with our Anti-CDK6 Polyclonal Antibody, now available in a 100µg size. Cyclin-dependent kinase 6 (CDK6) plays a crucial role in governing cell cycle progression, influencing cellular processes such as proliferation and differentiation. This polyclonal antibody, developed with precision, offers outstanding specificity and sensitivity, making it a valuable tool for researchers exploring cell cycle dynamics, cancer biology, and the molecular mechanisms underlying cellular growth.

With 100µg of this antibody, you'll have a substantial supply for various experiments, ensuring the continuity of your research. Uncover the intricacies of CDK6 and its involvement in cell cycle checkpoints, its interactions with cyclins, and its potential implications in cancer therapeutics and targeted therapies.

Product Name

CDK6 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

IMMUNOGEN INFORMATION

Immunogen

cyclin-dependent kinase 6

Synonyms

CDKN6

Observed MW

37 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

Q00534

IMAGES