anti- CDK8 antibody

Delve into the intricacies of cellular signaling and transcriptional regulation with our Anti-CDK8 Antibody, now available in a 100µg size. Cyclin-dependent kinase 8 (CDK8) is a pivotal player in the regulation of gene expression, influencing processes like transcriptional initiation and cell cycle progression. This monoclonal antibody offers exceptional specificity and sensitivity, making it an invaluable tool for researchers investigating cellular signaling, transcriptional control, and the molecular mechanisms governing gene regulation.

With 100µg of this antibody, you'll have an ample supply for various experiments, ensuring the continuity of your research. Unravel the mysteries of CDK8 and its role in transcriptional initiation, its interactions with transcriptional co-regulators, and its potential implications in gene therapy, cancer biology, and targeted therapies.

Product Name

CDK8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD(C-terminal domain) of the large subunit of RNA polymerase II(RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

IMMUNOGEN INFORMATION

Immunogen

cyclin-dependent kinase 8

Observed MW

53 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P49336

IMAGES