anti- CENPF antibody

Delve into the fascinating world of mitotic progression and spindle dynamics with our Anti-CENPF Antibody, now available in a 100µg size. CENPF, or centromere protein F, is a pivotal player in mitosis, contributing to proper spindle assembly and chromosome segregation. This monoclonal antibody offers remarkable specificity and sensitivity, making it an invaluable tool for researchers investigating cell division, mitotic checkpoint control, and the molecular mechanisms governing centromere attachment to the spindle.

With 100µg of this antibody, you'll have a substantial supply for various experiments, ensuring the continuity of your research. Explore the intricacies of CENPF and its role in spindle formation, its interactions with kinetochore proteins, and its potential implications in cancer research, mitotic disorders, and therapeutic interventions.

Product Name

CENPF antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.

IMMUNOGEN INFORMATION

Immunogen

centromere protein F, 350/400ka(mitosin)

APPLICATION

Tested Application

ELISA, IHC, IF

Recommended Dilution

IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P49454

IMAGES

Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab01585(CENPF Antibody) at dilution of 1:200