anti- CEP290 antibody

Explore the intricate world of cilia and ciliopathies with our Anti-CEP290 Antibody, an invaluable tool for cell biologists and geneticists. This antibody is meticulously designed to target Centrosomal Protein 290 (CEP290), a pivotal player in ciliary structure and function. With a generous 100µg size, you'll have an ample supply for your experiments.

CEP290 is essential for ciliary assembly and function, making it a central focus of research in cell biology and genetics. Our antibody undergoes rigorous testing to ensure high specificity and sensitivity, providing you with dependable results. Whether you're investigating ciliopathies, ciliary trafficking, or related pathways, our Anti-CEP290 Antibody is your trusted research companion.

This product is versatile and compatible with various applications, including Western blotting, immunofluorescence, and co-immunoprecipitation. Its high purity and specificity reduce background noise, enhancing the accuracy of your experiments. Unlock the mysteries of ciliary biology with confidence, equipped with our Anti-CEP290 Antibody.

Product Name

CEP290 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Studies in the Chlamydomonas model system has shown that the ciliary protein CEP290 is a critical component of these Y-link junctions. Additionally, numerous studies have demonstrated that CEP290’s function is critical for IFT—in CEP290 knockdown experiments, many proteins that would normally localize to the cilium fail to do so, and cilium formation is disrupted or absent. Mutations in CEP290 are accountable for cases of nephronophthisis, Leber congenital amaurosis and Joubert syndrome. In IF analtsis of HeLa cells, the white arrows show centrosome and cilium staining.

IMMUNOGEN INFORMATION

Immunogen

centrosomal protein 290kDa

Synonyms

BBS14, KIAA0373, NPHP6,LCA10, MKS4, Nephrocystin 6, rd16, SLSN6, Tumor antigen se2 2

Observed MW

290 kDa, 150-180 kDa, 80 kDa, 60 kDa

APPLICATION

Tested Application

ELISA, WB, IP, IHC, IF

Recommended Dilution

WB: 1:200-1:2000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

O15078

IMAGES

Immunohistochemistry of paraffin-embedded human placenta using FNab01602(CEP290 antibody) at dilution of 1:50

Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HeLa cells using FNab01602 ( CEP290 Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

IP result of anti-CEP290(FNab01602 for IP and Detection)with HeLa cells.

HeLa cells were subjected to SDS PAGE followed by western blot with FNab01602(CEP290 Antibody) at dilution of 1:600