anti- CEP63 antibody

Uncover the secrets of centrosome biology with our Anti-CEP63 Antibody, a powerful tool for researchers exploring cell division and centrosome dynamics. This antibody is specifically designed to target Centrosomal Protein 63 (CEP63), a critical player in centriole biogenesis and centrosome maturation. With a generous 100µg size, you'll have an ample supply for your experiments.

CEP63 is essential for the formation and stability of centrioles, which are pivotal for accurate chromosome segregation during cell division. Our antibody undergoes rigorous testing to ensure high specificity and sensitivity, providing you with reliable results. Whether you're studying centriole duplication, cilia formation, or related pathways, our Anti-CEP63 Antibody is your trusted research companion.

This product is versatile and compatible with various applications, including Western blotting, immunofluorescence, and immunoprecipitation. Its high purity and specificity minimize background noise, ensuring the accuracy of your findings. Explore the intricacies of centrosome biology with confidence, armed with our Anti-CEP63 Antibody.

Product Name

CEP63 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).

IMMUNOGEN INFORMATION

Immunogen

centrosomal protein 63kDa

Observed MW

57-75kd

APPLICATION

Tested Application

ELISA, WB, IF, IP, IHC

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q96MT8

IMAGES

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab01606(CEP63 Antibody) at dilution of 1:50

IP Result of anti-CEP63 (IP:FNab01606, 3ug; Detection:FNab01606 1:500) with HEK-293 cells lysate 1700ug.

human placenta tissue were subjected to SDS PAGE followed by western blot with FNab01606(CEP63 antibody) at dilution of 1:800