anti- CHFR antibody

Unlock the mysteries of cell cycle regulation and tumor suppression with our Anti-CHFR Antibody, available in a 100µg size. Checkpoint with Forkhead-Associated and Ring Finger (CHFR) is a critical protein involved in the control of cell division and DNA damage response.

This meticulously designed antibody offers unparalleled specificity and sensitivity, ensuring accurate detection of CHFR protein in your experiments. Researchers investigating cell cycle checkpoints, genomic stability, or related areas will appreciate the precision and reliability of this antibody.

Our Anti-CHFR Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Join the forefront of cell biology and cancer research and gain valuable insights into the role of CHFR in maintaining genomic integrity and preventing tumorigenesis.

Product Name

CHFR antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2(UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

IMMUNOGEN INFORMATION

Immunogen

checkpoint with forkhead and ring finger domains

Synonyms

RNF196

Observed MW

70-85 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q96EP1

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