anti- Chk1 antibody

Step into the world of cell cycle regulation and DNA damage response with our Polyclonal Anti-Chk1 Antibody, available in a 100µg size. Checkpoint kinase 1 (Chk1) plays a pivotal role in maintaining genome stability by coordinating cell cycle checkpoints and DNA repair.

This high-quality antibody is meticulously crafted to provide exceptional specificity and sensitivity, ensuring accurate detection of Chk1 protein in your experiments. Researchers investigating DNA damage signaling, checkpoint activation, or related areas will appreciate the precision and reliability of this antibody.

Our Polyclonal Anti-Chk1 Antibody undergoes rigorous quality control, guaranteeing consistent and reproducible results. Join the forefront of cell cycle research and uncover new insights into DNA damage response mechanisms with this indispensable tool.

Product Name

Chk1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

IMMUNOGEN INFORMATION

Immunogen

CHK1 checkpoint homolog (S. pombe)

Observed MW

54 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

O14757

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