anti- Chk2 antibody

Dive into the world of cellular signaling and DNA damage response with our Anti-Chk2 Antibody, available in a 100µg size. Checkpoint kinase 2 (Chk2) is a critical player in the DNA damage checkpoint pathway, ensuring genome stability and preventing the proliferation of damaged cells.

This high-quality polyclonal antibody is meticulously designed to provide exceptional specificity and sensitivity, ensuring accurate detection of Chk2 protein in your experiments. Researchers investigating DNA repair mechanisms, cell cycle regulation, or related fields will appreciate the precision and reliability of this antibody.

Our Anti-Chk2 Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Join the forefront of DNA damage response research and gain valuable insights into cellular mechanisms that safeguard genomic integrity.

Product Name

Chk2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

IMMUNOGEN INFORMATION

Immunogen

CHK2 checkpoint homolog (S. pombe)

Observed MW

70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

O96017

IMAGES