anti- CHMP2A antibody

Dive into the world of cellular membrane dynamics with our Anti-CHMP2A Antibody, available in a 100µg size. Charged multivesicular body protein 2A (CHMP2A) is a crucial component of the ESCRT-III complex, essential for membrane remodeling and vesicle formation.

This meticulously designed polyclonal antibody offers unparalleled specificity and sensitivity, ensuring accurate detection of CHMP2A protein in your experiments. Researchers studying endosomal trafficking, viral budding, or related areas will benefit from the precision and reliability of this antibody.

Our Anti-CHMP2A Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Take your research on membrane dynamics and intracellular transport to the next level with this essential tool.

Product Name

CHMP2A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis(PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase(PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses(HIV-1 and other lentiviruses). Involved in HIV-1 p6-and p9-dependent virus release.

IMMUNOGEN INFORMATION

Immunogen

chromatin modifying protein 2A

Synonyms

BC2, CHMP2

Observed MW

32 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

O43633

IMAGES