anti- CHMP4B antibody

Uncover the intricacies of intracellular membrane remodeling with our Anti-CHMP4B Antibody, available in a 100µg size. Charged multivesicular body protein 4B (CHMP4B) is a critical component of the ESCRT-III complex, responsible for membrane scission and vesicle formation.

This meticulously designed antibody offers unparalleled specificity and sensitivity, ensuring accurate detection of CHMP4B protein in your experiments. Researchers studying membrane abscission, cytokinesis, or related areas will benefit from the precision and reliability of this antibody.

Our Anti-CHMP4B Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Take your research on membrane dynamics and cellular division to the next level with this essential tool.

Product Name

CHMP4B antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.

IMMUNOGEN INFORMATION

Immunogen

chromatin modifying protein 4B

Synonyms

C20orf178, SHAX1

Observed MW

35 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

Q9H444

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