anti- CHMP6 antibody

Embark on a journey into the world of endosomal membrane dynamics with our Anti-CHMP6 Antibody, available in a 100µg size. Charged multivesicular body protein 6 (CHMP6) is a vital component of the ESCRT-III complex, crucial for membrane remodeling and endosomal sorting.

This high-quality polyclonal antibody is meticulously crafted to offer exceptional specificity and sensitivity, ensuring accurate detection of CHMP6 protein in your experiments. Researchers investigating endosomal trafficking, lysosomal biology, or related fields will appreciate the precision and reliability of this antibody.

Our Anti-CHMP6 Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Join the forefront of membrane biology research and uncover new insights into the mechanisms governing endosomal maturation and cargo sorting.

Product Name

CHMP6 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

IMMUNOGEN INFORMATION

Immunogen

chromatin modifying protein 6

Synonyms

VPS20

Observed MW

28-30 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q96FZ7

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