anti- CHOP; GADD153 antibody

Explore the intricacies of cellular stress responses and apoptosis with our Anti-CHOP; GADD153 Antibody, available in a 100µg size. C/EBP homologous protein (CHOP), also known as GADD153, is a key player in the unfolded protein response (UPR) and is associated with endoplasmic reticulum stress-induced apoptosis.

This high-quality polyclonal antibody is meticulously designed to provide exceptional specificity and sensitivity, ensuring accurate detection of CHOP protein in your experiments. Researchers investigating cellular stress, apoptosis, or related fields will appreciate the precision and reliability of this antibody.

Our Anti-CHOP; GADD153 Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Join the forefront of research into cellular stress pathways and gain valuable insights into the role of CHOP in UPR and apoptosis.

Product Name

CHOP; GADD153 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.

IMMUNOGEN INFORMATION

Immunogen

DNA-damage-inducible transcript 3

Synonyms

C/EBP homologous protein, C/EBP homologous protein 10, CEBPZ, CHOP, CHOP 10, CHOP; GADD153, CHOP10, DDIT 3, DDIT3, GADD153

Observed MW

30 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:5000

UNIPROT INFORMATION

UniProt ID

P35638

IMAGES

Tunicamycin treated HeLa cells were subjected to SDS PAGE followed by western blot with FNab01668(CHOP; GADD153 Antibody) at dilution of 1:1000