anti- CHRFAM7A antibody

Uncover the complexities of neuronal function with our Anti-CHRFAM7A Antibody, available in a 100µg size. CHRNA7 (cholinergic receptor nicotinic alpha 7) and CHRFAM7A (cholinergic receptor, nicotinic, alpha 7, and fetal-associated with risk for nicotine addiction) are key players in cholinergic neurotransmission and have been implicated in nicotine addiction.

This high-quality polyclonal antibody is meticulously designed to provide exceptional specificity and sensitivity, ensuring accurate detection of CHRFAM7A protein in your experiments. Researchers studying neurobiology, nicotine addiction, or related areas will appreciate the precision and reliability of this antibody.

Our Anti-CHRFAM7A Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Join the forefront of research into cholinergic receptors and gain valuable insights into their role in neuronal signaling and addiction.

Product Name

CHRFAM7A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

IMMUNOGEN INFORMATION

Immunogen

CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion

Observed MW

46 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

Q494W8

IMAGES

Immunohistochemistry of paraffin-embedded rat brain using FNab01673(CHRFAM7A antibody) at dilution of 1:100

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab01673( CHRFAM7A Antibody) at dilution of 1:1000