anti- CITED2 antibody

Explore the intricacies of transcriptional regulation and development with our Anti-CITED2 Antibody, available in a 100µg size. CITED2 (CBP/p300-Interacting Transactivator with ED-rich Tail 2) is a critical transcriptional co-regulator that exerts influence over gene expression during embryogenesis and tissue development.

This meticulously designed antibody offers unparalleled specificity and sensitivity, ensuring accurate detection of CITED2 protein in your experiments. Researchers studying developmental biology, transcriptional control, or related areas will appreciate the precision and reliability of this antibody.

Our high-quality Anti-CITED2 Antibody undergoes rigorous quality control, guaranteeing consistent and reproducible results. Dive into the forefront of research into transcriptional regulation and gain valuable insights into the role of CITED2 in shaping embryonic and tissue development.

Product Name

CITED2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm(LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium(AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.

IMMUNOGEN INFORMATION

Immunogen

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Synonyms

MRG1

Observed MW

24 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q99967

IMAGES

SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab01721(CITED2 antibody) at dilution of 1:500