anti- CLSPN antibody

Explore the fascinating world of DNA replication and cell cycle regulation with our Anti-CLSPN Antibody, available in a 100µg size. CLSPN (Claspin) is a crucial protein involved in the activation of the replication checkpoint during DNA replication stress.

This meticulously designed antibody offers exceptional specificity and sensitivity, ensuring accurate detection of CLSPN protein in your experiments. Researchers studying DNA repair, cell cycle control, or related areas will benefit from the precision and reliability of this antibody.

Our high-quality Anti-CLSPN Antibody undergoes rigorous quality control, guaranteeing consistent and reproducible results. Dive into the forefront of DNA replication research and gain valuable insights into the role of CLSPN in maintaining genomic integrity.

Product Name

CLSPN antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

IMMUNOGEN INFORMATION

Immunogen

claspin homolog(Xenopus laevis)

Observed MW

240 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IP

Recommended Dilution

WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9HAW4

IMAGES

IP Result of anti-Claspin (IP:FNab01775, 5ug; Detection:FNab01775 1:1000) with HEK-293 cells lysate 2400ug.

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab01775( Claspin antibody) at dilution of 1:300