anti- c-Met antibody

Investigate the dynamic functions of c-Met with our Anti-c-Met Antibody, available in a 100µg size. This high-quality antibody is your versatile tool for studying c-Met, a receptor tyrosine kinase involved in cell proliferation, motility, and tissue regeneration.

Engineered for precision and reliability, this antibody ensures exceptional sensitivity in applications such as western blotting, immunohistochemistry, and immunoprecipitation. Whether you're unraveling c-Met's role in cancer progression, tissue repair, or its interactions with ligands like HGF (hepatocyte growth factor), this antibody enhances your research capabilities.

c-Met is a key player in cellular signaling, influencing processes like cell scattering, angiogenesis, and tissue regeneration. Dysregulation of c-Met has been linked to various cancers, emphasizing its therapeutic relevance.

With our Anti-c-Met Antibody, you can delve into c-Met's functionality, explore its contributions to cancer biology, and potentially advance research in targeted therapies and regenerative medicine. Elevate your research in understanding the roles of c-Met in cellular processes with this precision antibody.

Product Name

c-Met antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

c-Met(also named as MET or HGFR) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. c-Met regulates many physiological processes including proliferation, scattering, morphogenesis and survival. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Overexpression and/or mutation of c-Met has been reported in various human malignancies, including lung cancer, breast cancer, head and neck cancer, gastric cancer, colorectal cancer, bladder cancer, uterine cervix carcinoma, and esophageal carcinoma, c-Met could serve as an important therapeutic target(PMID: 26036285). This antibody recognizes the N-term of c-Met.

IMMUNOGEN INFORMATION

Immunogen

met proto-oncogene(hepatocyte growth factor receptor)

Synonyms

AUTS9, c-Met, HGF receptor, HGF/SF receptor, HGFR, MET, Proto oncogene c Met, RCCP2, Scatter factor receptor, SF receptor, Tyrosine protein kinase Met

Observed MW

150 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

P08581

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab01786(MET Antibody) at dilution of 1:50

HeLa cells were subjected to SDS PAGE followed by western blot with FNab01786(MET antibody) at dilution of 1:500