anti- c-MYC antibody

Uncover the multifaceted functions of c-MYC with our Anti-c-MYC Antibody, available in a 100µg size as a polyclonal antibody. This versatile antibody is your ideal tool for investigating c-MYC, a transcription factor that plays a central role in cell growth, differentiation, and apoptosis.

Engineered for precision and reliability, this polyclonal antibody ensures exceptional sensitivity in applications such as western blotting, chromatin immunoprecipitation, and immunofluorescence. Whether you're probing c-MYC's roles in oncogenesis, stem cell biology, or its interactions with co-regulators, this antibody enhances your research capabilities.

c-MYC, a proto-oncogene, stands at the crossroads of cellular decisions, influencing gene expression patterns and cellular outcomes. Dysregulation of c-MYC is a hallmark of numerous cancers, making it a compelling focus of research.

With our Anti-c-MYC Antibody, you can delve into c-MYC's multifaceted functions, explore its contributions to cancer biology, and potentially advance research in therapeutics and gene regulation. Elevate your research in understanding the roles of c-MYC in cellular processes with this precision polyclonal antibody.

Product Name

c-MYC antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

MYC contains one basic helix-loop-helix(bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]

IMMUNOGEN INFORMATION

Immunogen

v-myc myelocytomatosis viral oncogene homolog(avian)

Synonyms

BHLHe39, c Myc, c-Myc, MRTL, MYC, Myc proto oncogene protein, Proto oncogene c Myc, Transcription factor p64

Observed MW

62-65 kDa, 50 kDa

APPLICATION

Tested Application

ELISA, WB, IP, IHC

Recommended Dilution

WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

P01106

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer using FNab01791(MYC antibody) at dilution of 1:50

IP Result of anti-MYC (IP: FNab01791, 3ug; Detection: FNab01791 1:500) with HL-60 cells lysate 1200ug.

Raji cells were subjected to SDS PAGE followed by western blot with FNab01791(MYC antibody) at dilution of 1:1000