anti- CNOT1 antibody

Unlock the intricacies of gene expression regulation with our Anti-CNOT1 Antibody, now available in a 100µg size. CNOT1 (CCR4-NOT Transcription Complex Subunit 1) is a key component of the CCR4-NOT complex, which plays a central role in controlling mRNA turnover and transcriptional regulation.

This meticulously designed antibody offers exceptional specificity and sensitivity, ensuring accurate detection of CNOT1 protein in your experiments. Researchers investigating RNA metabolism, post-transcriptional regulation, or related areas will benefit from the precision and reliability of this antibody.

Our high-quality Anti-CNOT1 Antibody undergoes rigorous quality control, guaranteeing consistent and reproducible results. Dive into the forefront of gene expression research and gain valuable insights into the role of CNOT1 in shaping the transcriptome and controlling cellular processes.

Product Name

CNOT1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity.

IMMUNOGEN INFORMATION

Immunogen

CCR4-NOT transcription complex, subunit 1

Synonyms

CDC39, KIAA1007, NOT1

Observed MW

240-250 kDa, 174 kDa

APPLICATION

Tested Application

ELISA, IHC, WB, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

A5YKK6

IMAGES

Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab01805(CNOT1 Antibody) at dilution of 1:200

IP Result of anti-CNOT1 (IP:FNab01805, 5ug; Detection:FNab01805 1:500) with mouse kidney tissue lysate 4000ug.

human brain tissue were subjected to SDS PAGE followed by western blot with FNab01805(CNOT1 antibody) at dilution of 1:800