anti- CNOT3 antibody

Uncover the mysteries of RNA metabolism and gene expression control with our Anti-CNOT3 Antibody, available in a 100µg size. CNOT3 (CCR4-NOT Transcription Complex Subunit 3) is a key component of the CCR4-NOT complex involved in mRNA deadenylation and has implications for mRNA stability and translation.

This meticulously designed antibody offers exceptional specificity and sensitivity, ensuring accurate detection of CNOT3 protein in your experiments. Researchers investigating post-transcriptional regulation, RNA turnover, or related areas will appreciate the accuracy and reliability of this antibody.

Our high-quality Anti-CNOT3 Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Dive into the forefront of molecular biology research and gain valuable insights into the role of CNOT3 in modulating mRNA dynamics and gene expression.

Product Name

CNOT3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem(ES) cell identity.

IMMUNOGEN INFORMATION

Immunogen

CCR4-NOT transcription complex, subunit 3

Synonyms

KIAA0691, LENG2, NOT3

Observed MW

120 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O75175

IMAGES

IP Result of anti-CNOT3 (IP:FNab01808, 4ug; Detection:FNab01808 1:1000) with HeLa cells lysate 3200ug.

Raji cells were subjected to SDS PAGE followed by western blot with FNab01808(CNOT3 antibody) at dilution of 1:500