anti- COCH antibody

Embark on a journey into the intricate world of auditory physiology with our Anti-COCH Antibody, available in a convenient 100µg size. COCH, a critical protein involved in inner ear function, is the focus of extensive research into hearing disorders, making this antibody an indispensable tool for your studies.

Our meticulously crafted antibody has undergone rigorous quality control measures to ensure specificity and sensitivity, enabling accurate and reproducible results in your experiments. Whether you're unraveling the mechanisms of hearing impairment or investigating cochlear development, this antibody will be your reliable partner.

With its 100µg size, you'll have an ample supply of antibody to fuel your research without the hassle of frequent reordering. Trust in our Anti-COCH Antibody to advance your scientific exploration of auditory biology and contribute to the understanding of hearing-related conditions.

Product Name

COCH antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

IMMUNOGEN INFORMATION

Immunogen

coagulation factor C homolog, cochlin (Limulus polyphemus)

Synonyms

COCH5B2

Observed MW

Refer to Figures

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

O43405

IMAGES

Immunohistochemistry of paraffin-embedded human prostate using FNab01824(COCH antibody) at dilution of 1:100

Immunofluorescence analysis of HeLa cells using FNab01824(COCH antibody) at dilution of 1:50